{"id":33306,"date":"2024-11-14T11:00:38","date_gmt":"2024-11-14T10:00:38","guid":{"rendered":"https:\/\/www.dexeuscampus.com\/?p=33306"},"modified":"2024-11-21T11:42:23","modified_gmt":"2024-11-21T10:42:23","slug":"cribratge-prenatal-anomalies-embarassos-fiv-dgp","status":"publish","type":"post","link":"https:\/\/www.dexeuscampus.com\/ca\/blog\/reproduccio-assistida\/cribratge-prenatal-anomalies-embarassos-fiv-dgp\/","title":{"rendered":"Un estudi q\u00fcestiona l\u2019efic\u00e0cia del cribratge prenatal d\u2019anomalies en embarassos per FIV amb DGP"},"content":{"rendered":"\t\t
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Article:<\/p>\n

Prenatal screening after preimplantation genetic testing for aneuploidy: time to evaluate old strategies<\/a><\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Palacios-Verd\u00fa MG, Rodr\u00edguez-Melc\u00f3n A, Rodr\u00edguez I, Racca A, Serra B, Albaiges G, Parriego M, Prats P.
Reprod Biomed Online. 2024 Jun;48(6):103761<\/strong>. DOI: 10.1016\/j.rbmo.2023.103761<\/a> <\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Malgrat el benefici te\u00f2ric d’un embri\u00f3 euploide cribrat mitjan\u00e7ant diagn\u00f2stic gen\u00e8tic preimplantacional per a aneuploidies (PGT-A, en les seves sigles en angl\u00e8s), no s’ha avaluat amb exactitud la influ\u00e8ncia del PGT-A en el cribratge prenatal d\u2018aneuploidies durant el primer trimestre. La majoria de les directrius institucionals recomanen que el cribratge prenatal de aneuploidies s’ofereixi a totes les pacients, independentment de la realitzaci\u00f3 del PGT-A. No obstant aix\u00f2, els algorismes de cribratge combinat no tenen en compte que l’embri\u00f3 ha estat seleccionat mitjan\u00e7ant PGT-A, i ofereixen estimacions de risc d’anomalies cromos\u00f2miques que es basen fonamentalment en l\u2019edat materna. Un estudi recent va reportar que el cribratge PGT-A no altera la probabilitat de sotmetre’s a procediments invasius de diagn\u00f2stic prenatal quan es realitza el cribratge prenatal convencional. <\/p>\n

Per aquest motiu, un equip de Dexeus Dona liderat per la Dra. Gabriela Palacios va realitzar un estudi amb la finalitat d\u2019avaluar l\u2019efic\u00e0cia del cribratge combinat de primer trimestre en gestacions aconseguides despr\u00e9s de PGT-A. En total, 20.237 dones van tenir seguiment prenatal en el centre d\u2019estudi i van ser incloses en l\u2019estudi. Les dones es van dividir en tres grups: embarassos \u00fanics concebuts mitjan\u00e7ant la transfer\u00e8ncia d\u2019un embri\u00f3 euploide cribrat amb PGT-A (n= 510); embarassos \u00fanics concebuts mitjan\u00e7ant FIV sense PGT-A (n= 3291); i embarassos \u00fanics concebuts de manera natural (n= 16.436). <\/p>\n

El cribratge combinat convencional per a embarassos concebuts mitjan\u00e7ant FIV amb PGT-A va tenir una especificitat del 91%; no es va poder calcular la sensibilitat perqu\u00e8 no va haver-hi casos de aneuploidia fetal en aquest grup. En el 89,1% dels embarassos concebuts mitjan\u00e7ant FIV amb PGT-A amb alt risc de trisomia 21, 18 o 13, el resultat estava relacionat amb una edat materna avan\u00e7ada (>35 anys en el moment del cribratge). <\/p>\n

D’acord amb els resultats, l’estrat\u00e8gia actual de cribratge combinat penalitza les gestacions sotmeses a PGT-A, a causa del gran pes de l’edat materna en el risc a priori, que \u00e9s major en les dones que duen a terme una FIV amb PGT-A. Segons els autors, aquesta estrat\u00e8gia condueix a la realitzaci\u00f3 de proves innecess\u00e0ries, amb el conseq\u00fcent cost econ\u00f2mic i emocional per a les pacients. Per aquest motiu proposen abandonar l’estrat\u00e8gia actual i establir un nou protocol per a aquestes pacients, que inclogui una ecografia entre les setmanes 11-14 per mesurar la transluc\u00e8ncia nucal i marcadors ecogr\u00e0fics addicionals, i en funci\u00f3 d’aquest resultat oferir una visita d’assessorament gen\u00e8tic per valorar alternatives de cribratge o de diagn\u00f2stic prenatal. <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Malgrat el benefici te\u00f2ric d\u2019un embri\u00f3 euploide cribrat mitjan\u00e7ant diagn\u00f2stic gen\u00e8tic preimplantacional per a aneuploidies, no s\u2019ha avaluat amb exactitud la influ\u00e8ncia del PGT-A en el cribratge prenatal d\u2018aneuploidies durant el primer trimestre.<\/p>\n","protected":false},"author":3,"featured_media":33273,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[206],"tags":[],"class_list":["post-33306","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reproduccio-assistida"],"yoast_head":"\nUn estudi q\u00fcestiona l\u2019efic\u00e0cia del cribratge prenatal d\u2019anomalies en embarassos per FIV amb DGP - Dexeus Campus<\/title>\n<meta name=\"description\" content=\"Malgrat el benefici te\u00f2ric d\u2019un embri\u00f3 euploide cribrat mitjan\u00e7ant diagn\u00f2stic gen\u00e8tic preimplantacional per a aneuploidies, no s\u2019ha avaluat amb exactitud la influ\u00e8ncia del PGT-A en el cribratge prenatal d\u2018aneuploidies durant el primer trimestre.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.dexeuscampus.com\/ca\/blog\/reproduccio-assistida\/cribratge-prenatal-anomalies-embarassos-fiv-dgp\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un estudi q\u00fcestiona l\u2019efic\u00e0cia del cribratge prenatal d\u2019anomalies en embarassos per FIV amb DGP - 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