{"id":37923,"date":"2026-02-12T14:30:37","date_gmt":"2026-02-12T13:30:37","guid":{"rendered":"https:\/\/www.dexeuscampus.com\/?p=37923"},"modified":"2026-03-04T14:31:53","modified_gmt":"2026-03-04T13:31:53","slug":"estudi-internacional-testosterona-transdermica-taxa-embaras-fiv","status":"publish","type":"post","link":"https:\/\/www.dexeuscampus.com\/ca\/blog\/reproduccio-assistida\/estudi-internacional-testosterona-transdermica-taxa-embaras-fiv\/","title":{"rendered":"Un estudi internacional liderat per Dexeus Dona demostra que l\u2019\u00fas de testosterona transd\u00e8rmica no augmenta la taxa d\u2019embar\u00e0s en FIV"},"content":{"rendered":"\t\t
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Gran part de les dones amb problemes d\u2019infertilitat presenten una reserva ov\u00e0rica baixa. Aquest fet sol tenir tamb\u00e9 un impacte en la seva resposta als tractaments d\u2019estimulaci\u00f3 ov\u00e0rica i en les possibilitats d\u2019aconseguir un embar\u00e0s si decideixen sotmetre\u2019s a una fecundaci\u00f3 in vitro<\/em> (FIV). Per aquest motiu, els especialistes investiguen diverses estrat\u00e8gies amb la finalitat de millorar els seus resultats reproductius. Una d\u2019elles \u00e9s l\u2019administraci\u00f3 de testosterona a trav\u00e9s de la pell.
<\/p>

Estudis inicials apuntaven cap a un possible efecte benefici\u00f3s de l\u2019administraci\u00f3 de testosterona en el desenvolupament dels fol\u00b7licles i en l\u2019acci\u00f3 de l\u2019hormona fol\u00b7liculoestimulant (FSH). No obstant aix\u00f2, la major part d\u2019aquests treballs no havien estat concloents a causa de limitacions pel que fa a la mida de la poblaci\u00f3 estudiada, la manca d\u2019un consens sobre la dosi aplicable o la durada del tractament.<\/p>

Per avaluar de manera definitiva la seva efectivitat, un equip internacional d\u2019investigadors, liderat pel Dr. Nikolaos Polyzos, director cient\u00edfic del Grup Dexeus Dona i president de la Fundaci\u00f3 Dexeus Dona<\/strong>, va decidir dur a terme un assaig cl\u00ednic multic\u00e8ntric, aleatoritzat, triple cec i controlat amb placebo sobre una \u00e0mplia mostra de pacients. En total hi van participar 288 dones d\u2019entre 18 i 43 anys de diferents pa\u00efsos europeus. De les 288 participants, 135 van ser assignades al grup que va rebre testosterona transd\u00e8rmica (5,5 mg en forma de gel) un cop al dia durant 9 setmanes abans d\u2019iniciar el tractament d\u2019estimulaci\u00f3 ov\u00e0rica, i 154 van rebre un placebo. Els investigadors van observar que les taxes d\u2019embar\u00e0s cl\u00ednic no diferien significativament: van ser del 15,7% en el grup al qual es va administrar testosterona i del 14,9% en el grup placebo. <\/p>

D\u2019acord amb els resultats, els autors conclouen que l\u2019administraci\u00f3 d\u2019andr\u00f2gens per via transd\u00e8rmica pr\u00e8viament al tractament d\u2019estimulaci\u00f3 ov\u00e0rica no comporta una millora significativa en els resultats reproductius, per la qual cosa no es recomana la seva utilitzaci\u00f3 de manera generalitzada com a tractament coadjuvant en cicles de FIV\/ICSI.<\/p>

En la investigaci\u00f3 hi han participat 10 centres de quatre pa\u00efsos europeus (Espanya, Su\u00efssa, B\u00e8lgica i Dinamarca), 4 d\u2019ells espanyols: l\u2019Hospital Universitari Dexeus, l\u2019Hospital Cl\u00ednic de Barcelona, l\u2019Hospital 12 d\u2019Octubre i l\u2019Hospital Universitari Quir\u00f3nsalud Madrid. El treball s\u2019ha publicat a la revista Nature Communications<\/em>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Enlla\u00e7 article de refer\u00e8ncia:<\/strong><\/p>

Transdermal testosterone gel vs placebo in women with diminished ovarian reserve prior to in vitro fertilization: a randomized, clinical trial<\/a><\/em><\/p>

Art\u00edcle original<\/a> publicat en Nature Communications<\/em><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Gran part de les dones amb problemes d\u2019infertilitat presenten una reserva ov\u00e0rica baixa. Aquest fet sol tenir tamb\u00e9 un impacte en la seva resposta als tractaments d\u2019estimulaci\u00f3 ov\u00e0rica i en les possibilitats d\u2019aconseguir un embar\u00e0s si decideixen sotmetre\u2019s a una fecundaci\u00f3 in vitro (FIV). Per aquest motiu, els especialistes investiguen diverses estrat\u00e8gies amb la finalitat de millorar els seus resultats reproductius. <\/p>\n","protected":false},"author":3,"featured_media":37911,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[206],"tags":[],"class_list":["post-37923","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reproduccio-assistida"],"yoast_head":"\nUn estudi internacional liderat per Dexeus Dona demostra que l\u2019\u00fas de testosterona transd\u00e8rmica no augmenta la taxa d\u2019embar\u00e0s en FIV - Dexeus Campus<\/title>\n<meta name=\"description\" content=\"Gran part de les dones amb problemes d\u2019infertilitat presenten una reserva ov\u00e0rica baixa. 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