{"id":11291,"date":"2021-07-26T15:00:15","date_gmt":"2021-07-26T14:00:15","guid":{"rendered":"https:\/\/www.dexeuscampus.com\/sin-categorizar\/paternal-age-is-associated-with-a-higher-prevalence-of-mosaic-embryo\/"},"modified":"2024-05-13T11:03:19","modified_gmt":"2024-05-13T10:03:19","slug":"paternal-age-associated-higher-prevalence-mosaic-embryo","status":"publish","type":"post","link":"https:\/\/www.dexeuscampus.com\/en\/blog\/assisted-reproduction\/paternal-age-associated-higher-prevalence-mosaic-embryo\/","title":{"rendered":"Paternal age is associated with a higher prevalence of mosaic embryo"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"11291\" class=\"elementor elementor-11291 elementor-4998\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6fe8da35 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6fe8da35\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4ac1c556\" data-id=\"4ac1c556\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4e825446 elementor-widget elementor-widget-text-editor\" data-id=\"4e825446\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A retrospective study carried out by researchers from the <strong>Dexeus Mujer<\/strong>Reproductive Medicine Service, specialized in preimplantation genetic diagnosis and led by researcher <strong><a href=\"https:\/\/en.dexeus.com\/who-we-are\/our-centers\/medical-team\/lluc-coll-lujan\" target=\"_blank\" rel=\"noopener\">Lluc Coll<\/a><\/strong>, has analysed what factors can influence the presence of mosaicism in preimplantation embryos.<\/p>\n<p>The work was carried out from a total of 482 IVF cycles performed between October 2017 and October 2019 and intrinsic and extrinsic factors potentially associated with the prevalence of mosaicism were studied, such as maternal and paternal age, antral follicle count, the cumulus-oocyte complexes recovered, the body mass index of the woman, the indication of PGT-A, the concentration of sperm, the total dose of gonadotropins, the quality of the embryo and the day of blastocyst formation, the use of two different commercial culture media, and the biopsy operator.<\/p>\n<p>The prevalence of mosaicism was 13.9%. According to the authors, the results suggest notable differences in the mechanisms that generate segmental mosaicism and that of the whole chromosome, indicating that they may deserve different consideration when studying them and prioritizing their transfer. Likewise, the male factor and specifically the paternal age seem to be an intrinsic factor associated with mosaicism, which is why they suggest that a specific evaluation of this element should be carried out in future studies.<\/p>\n<p><strong>Reference study:<\/strong><\/p>\n<p><a style=\"font-size: 16px; font-style: italic; color: #4f91cd; text-decoration: underline;\" title=\"Prevalence, types and possible factors influencing mosaicism in IVF blastocysts: results from a single setting\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33153932\/\" target=\"_blank\" rel=\"noopener\">Prevalence, types and possible factors influencing mosaicism in IVF blastocysts: results from a single setting<\/a><br \/><span style=\"font-size: 16px;\">Lluc Coll, M\u00f2nica Parriego, S\u00edlvia Mateo, S\u00edlvia Garc\u00eda-Moncl\u00fas, Ignacio Rodr\u00edguez, Montserrat Boada, B.Coroleu, N P Polyzos, F Vidal, A Veiga.<\/span><br \/><span style=\"font-size: 16px; font-style: italic;\">Reprod Biomed Online 2021 Jan;42(1):55-65. doi: 10.1016\/j.rbmo.2020.09.025.<\/span><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>A retrospective study carried out by researchers from the Dexeus Mujer Reproductive Medicine Service, specialized in preimplantation genetic diagnosis and led by researcher Lluc Coll, has analysed what factors can influence the presence&#8230;<\/p>\n","protected":false},"author":3,"featured_media":5001,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[205],"tags":[249,247,250,248,233],"class_list":["post-11291","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-assisted-reproduction","tag-lluc-coll-en","tag-mosaic-embryo","tag-mosaicism","tag-preimplantation-genetic-diagnosis","tag-reproduction"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - 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