{"id":25598,"date":"2023-06-02T10:00:21","date_gmt":"2023-06-02T09:00:21","guid":{"rendered":"https:\/\/www.dexeuscampus.com\/?p=25598"},"modified":"2023-06-02T12:23:17","modified_gmt":"2023-06-02T11:23:17","slug":"association-genotype-fshr-prognosis-ivf","status":"publish","type":"post","link":"https:\/\/www.dexeuscampus.com\/en\/blog\/assisted-reproduction\/association-genotype-fshr-prognosis-ivf\/","title":{"rendered":"An association between the FSHR genotype and the reproductive prognosis in IVF is confirmed"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"25598\" class=\"elementor elementor-25598 elementor-25534\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-276cf6e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"276cf6e\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-727f876\" data-id=\"727f876\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-38b8d29 elementor-widget elementor-widget-text-editor\" data-id=\"38b8d29\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A new multicentre study led by <strong>Dr Nikolaos Polyzos<\/strong>, Head in the Dexeus Mujer Reproduction Service, has studied whether there could be any association between different genetic variants in the FSHR sequence and the outcomes of reproductive treatments in patients with infertility problems.<\/p>\n<p>The work was conducted between November 2016 and June 2019 in Spain, Belgium and Vietnam and included 351 patients aged &lt;years and undergoing IVF with a predicted normal response with fixed dose of 150 IU of FSHR in an antagonist protocol. Genotyping was performed for three FSHR sequence variants (c.919A&gt;G, c.2039A&gt;G, c.-29G&gt;A) and one FSHB (c.-211G&gt;T). Clinical pregnancy rate (CPR), live birth rate (LBR) and miscarriage rate at first embryo transfer, as well as cumulative live birth rate (CLBR) were compared between genotypes.<\/p>\n<p>The results evidence a previously unreported association between the c.919A&gt;G variant genotype GG and higher CPR and CLBR in infertile patients and reinforce a potential role of genetic background in predicting reproductive prognosis after IVF.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-67b0bbc elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"67b0bbc\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-827b9df\" data-id=\"827b9df\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ef5e46d elementor-widget elementor-widget-html\" data-id=\"ef5e46d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p><strong>Reference article:<\/strong><br><a style=\"font-size: 16px; font-style: italic; color: #4f91cd; text-decoration: underline;\" title=\"Association between sequence variants in the FSHR gene and reproductive outcomes following IVF in predicted normoresponders\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37130623\/\" target=\"_blank\" rel=\"noopener\">Association between sequence variants in the FSHR gene and reproductive outcomes following IVF in predicted normoresponders<\/a><br><span style=\"font-size: 16px; font-style: italic;\">Ana Raquel Neves, Sandra Garcia, Lan Tn Vuong, Christophe Blockeel, Gemma Arroyo, Claudia Spits, Toan D Pham, Tuong M Ho, Herman Tournaye, Nikolaos P Polyzos.<\/span><br><span style=\"font-size: 16px; font-style: italic;\">Reprod Biomed Online . 2023 May;46(5):826-834. doi: 10.1016\/j.rbmo.2023.01.013.<\/span><\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>A new multicentre study led by Dr. Nikolaos Polyzos, Head in the Dexeus Mujer Reproduction Service, has studied whether there could be any association between different genetic variants in the FSHR sequence and the outcomes of reproductive treatments&#8230;<\/p>\n","protected":false},"author":3,"featured_media":25537,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[205],"tags":[],"class_list":["post-25598","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-assisted-reproduction"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - 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