{"id":33499,"date":"2024-11-20T12:40:28","date_gmt":"2024-11-20T11:40:28","guid":{"rendered":"https:\/\/www.dexeuscampus.com\/blog\/uncategorized\/new-ovarian-stimulation-strategy-leads-to-more-high-quality-embryos\/"},"modified":"2024-11-21T11:40:10","modified_gmt":"2024-11-21T10:40:10","slug":"new-ovarian-stimulation-strategy","status":"publish","type":"post","link":"https:\/\/www.dexeuscampus.com\/en\/blog\/assisted-reproduction\/new-ovarian-stimulation-strategy\/","title":{"rendered":"New ovarian stimulation strategy leads to more high-quality embryos"},"content":{"rendered":"\t\t
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Article:<\/p>\n

Double versus single stimulation in young low prognosis patients followed by a fresh embryo transfer: a randomized controlled trial (DUOSTIM-fresh)<\/a><\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Racca A, Rodriguez I, Garcia S, Arroyo G, Polyzos NP.
Hum Reprod. 2024 Jun 6:deae104<\/strong>. DOI: 10.1093\/humrep\/deae104<\/a> <\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Ovarian stimulation in both the follicular and luteal phases of the same cycle is an innovative strategy to retrieve more oocytes in a shorter time frame. This approach is therefore particularly attractive for patients with a poor ovarian response. The three current limitations of double stimulation are: it is unclear whether the outcomes of the second (luteal) wave are due to the second stimulation or to a carry-over effect from the previous follicular stimulation; the desynchronisation between the endometrium and the ovaries; and finally, the lack of robust evidence. <\/p>\n

For this reason, a team of researchers from the Reproductive Medicine Department at Dexeus Mujer has conducted a randomised clinical trial, called DUOSTIM fresh, comparing two different ovarian stimulation protocols: a double stimulation cycle versus a single stimulation cycle followed by fresh embryo transfer.<\/p>\n

The primary outcome was the number of good quality blastocysts obtained, while secondary outcomes included the results of fresh embryo transfer (clinical pregnancy, miscarriage). A total of 120 women participated in the study between October 2020 and October 2022. <\/p>\n

In the end, 107 patients were analysed, with 53 in the research arm (DUOSTIM fresh) and 54 in the control arm (single stimulation). DUOSTIM fresh resulted in a significantly higher number of good quality blastocysts compared to single stimulation. Also, the mean percentage of cycles with embryo transfer was similar between the two groups (62.3% and 51.9% for double stimulation and single stimulation, respectively). No significant differences were found in clinical outcomes following fresh embryo transfer, with an ongoing pregnancy rate of 24.5% for DUOSTIM fresh versus 22.2% for conventional IVF. <\/p>\n

Although DUOSTIM fresh did not increase clinical pregnancy rates, the higher number of good quality blastocysts produced after DUOSTIM makes it a valid strategy to consider in certain patient groups.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Ovarian stimulation in both the follicular and luteal phases of the same cycle is an innovative strategy to retrieve more oocytes in a shorter time frame. This approach is therefore particularly attractive for patients with a poor ovarian response.<\/p>\n","protected":false},"author":3,"featured_media":33271,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[205],"tags":[],"class_list":["post-33499","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-assisted-reproduction"],"yoast_head":"\nNew ovarian stimulation strategy leads to more high-quality embryos - Dexeus Campus<\/title>\n<meta name=\"description\" content=\"Ovarian stimulation in both the follicular and luteal phases of the same cycle is an innovative strategy to retrieve more oocytes in a shorter time frame. 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