{"id":38344,"date":"2026-06-01T11:49:12","date_gmt":"2026-06-01T10:49:12","guid":{"rendered":"https:\/\/www.dexeuscampus.com\/blog\/uncategorized\/a-study-suggests-updating-pre-eclampsia-screening-after-identifying-a-bias-in-ivf-pregnancies-conceived-in-artificial-cycles\/"},"modified":"2026-06-01T13:23:30","modified_gmt":"2026-06-01T12:23:30","slug":"study-pre-eclampsia-screening-ivf-pregnancies","status":"publish","type":"post","link":"https:\/\/www.dexeuscampus.com\/en\/blog\/obstetrics\/study-pre-eclampsia-screening-ivf-pregnancies\/","title":{"rendered":"A study suggests updating pre-eclampsia screening after identifying a bias in IVF pregnancies conceived in artificial cycles"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"38344\" class=\"elementor elementor-38344 elementor-38319\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-51ca307 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"51ca307\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5090955\" data-id=\"5090955\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4c9f52a elementor-widget elementor-widget-html\" data-id=\"4c9f52a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p style=\"margin: 0px 0px 0px 0px; text-align: left; font-size: 17px; font-weight: 600; font-style: italic; color: #537b8d;\">Article:<\/p>\r\n<p style=\"margin: 5px 0px 0px 0px; text-align: left; font-size: 19px; font-weight: 400; font-style: italic; line-height: 22px; color: #4f91cd\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41730489\/\" target=\"_blank\" rel=\"noopener\" style=\"font-size: 19px; font-weight: 400; color: #4f91cd; text-decoration: underline;\" title=\"Artificial cycle frozen embryo transfer improves uterine perfusion during later pregnancy but is associated with higher preeclampsia incidence\">Artificial cycle frozen embryo transfer improves uterine perfusion during later pregnancy but is associated with higher preeclampsia incidence<\/a><\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-93372b5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"93372b5\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-c29f74f\" data-id=\"c29f74f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5513404 elementor-widget elementor-widget-html\" data-id=\"5513404\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p style=\"margin: 0px 0px; text-align: left; font-size: 16px; font-weight: 400; font-style: italic;\">Valeria Donno, Pilar Prats, Marta Plancha, Ignacio Rodriguez, Kypros Nicolaides, Nikolaos P Polyzos.<br><strong>Am J Obstet Gynecol<\/strong>. 2026 Feb 21:S0002-9378(26)00103-1.<br\/>DOI: <a id=\"enlace_doi\" href=\"https:\/\/doi.org\/10.1016\/j.ajog.2026.02.031\" target=\"_blank\" rel=\"noopener\" style=\"font-size: 16px; color: #4f91cd; text-decoration: underline;\" title=\"10.1016\/j.ajog.2026.02.031\">10.1016\/j.ajog.2026.02.031<\/a> <\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-3682410\" data-id=\"3682410\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-71cb22d elementor-widget elementor-widget-image\" data-id=\"71cb22d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41730489\/\" target=\"_blank\" title=\"pubmed\">\n\t\t\t\t\t\t\t<img decoding=\"async\" width=\"250\" height=\"90\" src=\"https:\/\/www.dexeuscampus.com\/wp-content\/uploads\/2024\/03\/logo-ajog.png\" class=\"attachment-full size-full wp-image-29853\" alt=\"AJOG Global Reports\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7e6857e8 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7e6857e8\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-44f2be36\" data-id=\"44f2be36\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7cbbcc68 elementor-widget elementor-widget-text-editor\" data-id=\"7cbbcc68\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A large\u2011scale study conducted by Dexeus Mujer and recently published in the <strong><em>American Journal of Obstetrics &#038; Gynecology<\/em><\/strong><em>, <\/em>has shown that pregnancies achieved through frozen embryo transfer in an artificial cycle exhibit significantly lower uterine vascular resistance during the second and third trimester, yet display an incidence of pre\u2011eclampsia up to four times higher than other modes of conception.<\/p><p>The study analysed 27,495 singleton pregnancies monitored between 2010 and 2024, including natural conceptions, ovulation induction, insemination, fresh embryo transfer IVF and frozen embryo transfer IVF. The results reveal that artificial\u2011cycle frozen embryo transfers show the lowest uterine pulsatility index values in the second and third trimester, compared with natural pregnancies or natural\u2011cycle frozen embryo transfers. <\/p><p>Despite this improved uterine perfusion, these pregnancies presented a 5.2% incidence of pre\u2011eclampsia, markedly higher than that observed in natural pregnancies (1.4%), natural\u2011cycle frozen embryo transfers (1.1%) or fresh IVF (2.2%). The authors note that this discrepancy highlights a systematic bias in current screening algorithms, which interpret low resistance values as an indicator of low risk. <\/p><p>The <strong>Dr Valeria Donno<\/strong>, lead author, emphasises that the findings reinforce the urgent need to revise second\u2011 and third\u2011trimester screening algorithms to ensure early identification and appropriate clinical management of high\u2011risk pregnancies.<\/p><p>The study included the participation of <strong>Prof. Kypros Nicolaides<\/strong>, a global pioneer and leading figure in the development of fetal medicine.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>A large\u2011scale study conducted by Dexeus Mujer has shown that pregnancies achieved through frozen embryo transfer in an artificial cycle exhibit significantly lower uterine vascular resistance during the second and third trimester, yet display an incidence of pre\u2011eclampsia up to four times higher than other modes of conception.<\/p>\n","protected":false},"author":3,"featured_media":38322,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[203],"tags":[],"class_list":["post-38344","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-obstetrics"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - 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